InnateDB Protein
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IDBP-28548.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DNAJC15
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Protein Name
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DnaJ (Hsp40) homolog, subfamily C, member 15
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368523
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InnateDB Gene
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IDBG-28544 (DNAJC15)
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Protein Structure
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Function |
Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269PubMed:23263864}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000269PubMed:23263864, ECO:0000269PubMed:23530063}; Single-pass membrane protein {ECO:0000269PubMed:23263864, ECO:0000269PubMed:23530063}.
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Disease Associations |
Note=Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
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Tissue Specificity |
Expressed at highest levels in heart, followed by liver and kidney. {ECO:0000269PubMed:11358853, ECO:0000269PubMed:23530063}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0009267
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cellular response to starvation
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GO:0015031
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protein transport
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GO:0019216
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regulation of lipid metabolic process
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GO:0031333
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negative regulation of protein complex assembly
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GO:1902957
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negative regulation of mitochondrial electron transport, NADH to ubiquinone
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Cellular Component |
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PDB ID |
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InterPro |
IPR001623
DnaJ domain
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PFAM |
PF00226
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PRINTS |
PR00625
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PIRSF |
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SMART |
SM00271
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y5T4
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PhosphoSite |
PhosphoSite-Q9Y5T4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
29103
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UniGene |
Hs.438830
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RefSeq |
NP_037370
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HUGO |
HGNC:20325
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OMIM |
615339
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CCDS |
CCDS9388
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HPRD |
13238
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IMGT |
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EMBL |
AF126743
AK311866
AL445217
AY248898
AY512565
BC010910
BC095400
CH471075
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GenPept |
AAD38506
AAH10910
AAH95400
AAP20049
AAS80157
BAG34807
CAI13480
EAX08688
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