InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC38A2

Summary

InnateDB Protein

IDBP-28557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC38A2

Protein Name

solute carrier family 38, member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000256689

InnateDB Gene

IDBG-28555 (SLC38A2)

Protein Structure

UniProt Annotation

Function

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta. {ECO:0000269PubMed:10930503, ECO:0000269PubMed:15922329}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15561425, ECO:0000269PubMed:16616430}; Multi-pass membrane protein {ECO:0000269PubMed:15561425, ECO:0000269PubMed:16616430}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level). {ECO:0000269PubMed:10930503, ECO:0000269PubMed:15561425, ECO:0000269PubMed:16616430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015171	amino acid transmembrane transporter activity
GO:0015293	symporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006865	amino acid transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0014047	glutamate secretion
GO:0055085	transmembrane transport