Version 5.4
Homo sapiens Protein: DET1
Summary
InnateDB Protein IDBP-28650.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DET1
Protein Name de-etiolated homolog 1 (Arabidopsis)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000268148
InnateDB Gene IDBG-28648 (DET1)
Protein Structure
UniProt Annotation
Function Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. {ECO:0000269PubMed:14739464}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in the ovary, some lymphoid organs and resting leukocytes. {ECO:0000269PubMed:14739464}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR019138 De-etiolated protein 1, Det1
PFAM PF09737
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7L5Y6
PhosphoSite PhosphoSite-Q7L5Y6
TrEMBL A0A024RC56
UniProt Splice Variant
Entrez Gene 55070
UniGene Hs.690871
RefSeq NP_001137546
HUGO HGNC:25477
OMIM 608727
CCDS CCDS45344
HPRD 13140
IMGT
EMBL AK000965 AK054603 BC001242 BC109060 BC109061 CH471101
GenPept AAH01242 AAI09061 AAI09062 BAA91447 BAG51398 EAX02003 EAX02004

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca