InnateDB Protein
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IDBP-28745.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AFF1
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Protein Name
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AF4/FMR2 family, member 1
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Synonyms
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AF4; MLLT2; PBM1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000305689
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InnateDB Gene
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IDBG-28741 (AFF1)
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Protein Structure
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Function |
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
Note=A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
37
[view]
|
Protein-Protein |
36
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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|
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Molecular Function |
Accession |
GO Term |
GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007797
Transcription factor AF4/FMR2
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PFAM |
PF05110
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P51825
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PhosphoSite |
PhosphoSite-P51825
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TrEMBL |
Q712L1
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UniProt Splice Variant |
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Entrez Gene |
4299
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UniGene |
Hs.607658
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RefSeq |
NP_005926
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HUGO |
HGNC:7135
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OMIM |
159557
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CCDS |
CCDS3616
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HPRD |
08871
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IMGT |
|
EMBL |
AC092658
AC093779
AC093827
AJ238093
AK300364
BC114930
CH471057
L13773
L25050
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GenPept |
AAA36642
AAA58360
AAI14931
AAY40899
BAG62103
CAB52416
EAX05979
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