InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: REM2

Summary

InnateDB Protein

IDBP-2881.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

REM2

Protein Name

RAS (RAD and GEM)-like GTP binding 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000267396

InnateDB Gene

IDBG-2879 (REM2)

Protein Structure

UniProt Annotation

Function

Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR013684 Mitochondrial Rho-like
IPR017358 Small GTPase superfamily, GEM/REM/Rad
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF08477

PRINTS

PR00449

PIRSF

PIRSF038017

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References