InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCNT4

Summary

InnateDB Protein

IDBP-28846.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCNT4

Protein Name

glucosaminyl (N-acetyl) transferase 4, core 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000317027

InnateDB Gene

IDBG-28844 (GCNT4)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity. {ECO:0000269PubMed:10753916}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in thymus. Weakly expressed in pancreas, peripheral blood leukocytes, placenta, small intestine and stomach. Barely detectable in liver, spleen, lung and lymph node. {ECO:0000269PubMed:10753916}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008375	acetylglucosaminyltransferase activity

Biological Process

GO:0002121	inter-male aggressive behavior
GO:0005975	carbohydrate metabolic process
GO:0006493	protein O-linked glycosylation
GO:0016266	O-glycan processing
GO:0042403	thyroid hormone metabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0048729	tissue morphogenesis
GO:0048872	homeostasis of number of cells
GO:0060993	kidney morphogenesis