Version 5.4
Homo sapiens Protein: ENDOU
Summary
InnateDB Protein IDBP-28892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENDOU
Protein Name endonuclease, polyU-specific
Synonyms P11; PP11; PRSS26;
Species Homo sapiens
Ensembl Protein ENSP00000229003
InnateDB Gene IDBG-28890 (ENDOU)
Protein Structure
UniProt Annotation
Function Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini. {ECO:0000269PubMed:18936097}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Placental-specific, but also associated with various malignant neoplasms.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004521 endoribonuclease activity
GO:0005044 scavenger receptor activity
GO:0008083 growth factor activity
GO:0008236 serine-type peptidase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0030145 manganese ion binding
GO:0030247 polysaccharide binding
Biological Process
GO:0006508 proteolysis
GO:0006898 receptor-mediated endocytosis
GO:0006955 immune response
GO:0007565 female pregnancy
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001212 Somatomedin B domain
IPR018998 Endoribonuclease XendoU
IPR020436 Somatomedin B, chordata
PFAM PF01033
PF09412
PRINTS PR00022
PIRSF
SMART SM00201
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P21128
PhosphoSite PhosphoSite-
TrEMBL B7Z3J4
UniProt Splice Variant
Entrez Gene 8909
UniGene Hs.997
RefSeq NP_006016
HUGO HGNC:14369
OMIM 606720
CCDS CCDS8754
HPRD 12110
IMGT
EMBL AC004241 AK075446 AK295963 AK300169 AK314688 BC069715 BC074763 BC111782 CH471111 M32402 M36109
GenPept AAA36464 AAA36465 AAH69715 AAH74763 AAI11783 BAG37240 BAG52139 BAH12230 BAH13227 EAW57940

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca