InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KPNA7

Summary

InnateDB Protein

IDBP-28957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KPNA7

Protein Name

karyopherin alpha 7 (importin alpha 8)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000330878

InnateDB Gene

IDBG-28955 (KPNA7)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20701745}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0006606	protein import into nucleus
GO:0019221	cytokine-mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000225 Armadillo
IPR000357 HEAT
IPR002652 Importin-alpha, importin-beta-binding domain
IPR016024 Armadillo-type fold

PFAM

PF00514
PF02985
PF01749

PRINTS

PIRSF

SMART

SM00185

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A9QM74

PhosphoSite

PhosphoSite-A9QM74

TrEMBL

UniProt Splice Variant

Entrez Gene

402569

UniGene

Hs.253050

RefSeq

NP_001139187

HUGO

HGNC:21839

OMIM

614107

CCDS

CCDS47651

HPRD

IMGT

EMBL

CH236956 EU126604

GenPept

ABW96272 EAL23884