Version 5.4
Homo sapiens Protein: HSD17B11
Summary
InnateDB Protein IDBP-28972.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD17B11
Protein Name hydroxysteroid (17-beta) dehydrogenase 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351035
InnateDB Gene IDBG-28970 (HSD17B11)
Protein Structure
UniProt Annotation
Function Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart. {ECO:0000269PubMed:10800688, ECO:0000269PubMed:11165019, ECO:0000269PubMed:12697717, ECO:0000269PubMed:9888557}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0016229 steroid dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006710 androgen catabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005811 lipid particle
Protein Structure and Domains
PDB ID
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013968 Polyketide synthase, KR
PFAM PF00106
PF08659
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NBQ5
PhosphoSite PhosphoSite-Q8NBQ5
TrEMBL
UniProt Splice Variant
Entrez Gene 51170
UniGene Hs.594923
RefSeq NP_057329
HUGO HGNC:22960
OMIM 612831
CCDS CCDS3619
HPRD 10881
IMGT
EMBL AC108516 AF126780 AF273056 AK075348 AY358553 BC008650 BC014327 BC016367 BC021673 BC036001
GenPept AAF06939 AAH08650 AAH14327 AAH16367 AAH21673 AAH36001 AAM44459 AAQ88917 BAC11560

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca