InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPARCL1

Summary

InnateDB Protein

IDBP-29105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPARCL1

Protein Name

SPARC-like 1 (hevin)

Synonyms

MAST 9; MAST9; PIG33; SC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000282470

InnateDB Gene

IDBG-29103 (SPARCL1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007165

signal transduction

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR002350 Kazal domain
IPR003645 Follistatin-like, N-terminal
IPR015369 Follistatin/Osteonectin EGF domain
IPR016359 SPARC-like protein 1
IPR019577 SPARC/Testican, calcium-binding domain

PFAM