InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF2F2

Summary

InnateDB Protein

IDBP-29152.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2F2

Protein Name

general transcription factor IIF, polypeptide 2, 30kDa

Synonyms

BTF4; RAP30; TF2F2; TFIIF;

Species

Homo sapiens

Ensembl Protein

ENSP00000340823

InnateDB Gene

IDBG-29148 (GTF2F2)

Protein Structure

UniProt Annotation

Function

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA- helicase activity. {ECO:0000269PubMed:2477704}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10454543}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006200	ATP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005674	transcription factor TFIIF complex
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR003196 Transcription initiation factor IIF, beta subunit
IPR011039 Transcription Factor IIF, Rap30/Rap74, interaction
IPR016640 Transcription initiation factor IIF, beta subunit, subgroup

PFAM

PF02270

PRINTS

PIRSF

PIRSF015849

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13984