Version 5.4
Homo sapiens Protein: TMEM205
Summary
InnateDB Protein IDBP-29158.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM205
Protein Name transmembrane protein 205
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000346954
InnateDB Gene IDBG-29156 (TMEM205)
Protein Structure
UniProt Annotation
Function In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin. {ECO:0000269PubMed:20589834}.
Subcellular Localization Membrane {ECO:0000269PubMed:20589834}; Multi-pass membrane protein {ECO:0000269PubMed:20589834}. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.
Disease Associations
Tissue Specificity Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level). {ECO:0000269PubMed:20589834}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UW68
PhosphoSite PhosphoSite-Q6UW68
TrEMBL K7ER05
UniProt Splice Variant
Entrez Gene 374882
UniGene Hs.8036
RefSeq XP_005259958
HUGO HGNC:29631
OMIM 613771
CCDS CCDS32909
HPRD 18605
IMGT
EMBL AC024575 AK291979 AY358949 BC064948 BC091472 CH471106
GenPept AAH64948 AAH91472 AAQ89308 BAF84668 EAW84191 EAW84192 EAW84193 EAW84197

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca