InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF15

Summary

InnateDB Protein

IDBP-29197.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF15

Protein Name

kinesin family member 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000324020

InnateDB Gene

IDBG-29195 (KIF15)

Protein Structure

UniProt Annotation

Function

Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity). Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis, colon, thymus and in breast cancer. {ECO:0000269PubMed:12747765}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003774	motor activity
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007067	mitotic nuclear division
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005873	plus-end kinesin complex
GO:0005874	microtubule
GO:0016020	membrane