Version 5.4
Homo sapiens Protein: PDGFA
Summary
InnateDB Protein IDBP-292445.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDGFA
Protein Name platelet-derived growth factor alpha polypeptide
Synonyms PDGF-A; PDGF1;
Species Homo sapiens
Ensembl Protein ENSP00000384673
InnateDB Gene IDBG-6078 (PDGFA)
Protein Structure
UniProt Annotation
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). {ECO:0000250}.
Subcellular Localization Secreted. Note=Released by platelets upon wounding.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
Biological Process
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR006782 Platelet-derived growth factor, N-terminal
PFAM PF04692
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-P04085
TrEMBL
UniProt Splice Variant
Entrez Gene 5154
UniGene Hs.714993
RefSeq
HUGO HGNC:8799
OMIM 173430
CCDS
HPRD 01424
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca