InnateDB Protein
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IDBP-29248.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TP53INP1
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Protein Name
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tumor protein p53 inducible nuclear protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344215
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InnateDB Gene
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IDBG-29246 (TP53INP1)
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Protein Structure
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Function |
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. {ECO:0000269PubMed:11511362, ECO:0000269PubMed:22421968, ECO:0000269PubMed:22470510}.
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Subcellular Localization |
Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:11511362, ECO:0000269PubMed:12067065}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96A56
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PhosphoSite |
PhosphoSite-
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TrEMBL |
A0A024R9C8
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UniProt Splice Variant |
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Entrez Gene |
94241
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UniGene |
Hs.719508
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RefSeq |
NP_150601
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HUGO |
HGNC:18022
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OMIM |
606185
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CCDS |
CCDS6265
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HPRD |
09367
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IMGT |
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EMBL |
AB017926
AB017927
AB062056
AF409114
AF409115
AK315071
BC074813
BC074868
CH471060
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GenPept |
AAH74813
AAH74868
AAL04513
AAL04514
BAB62149
BAB62150
BAB62151
BAB62152
BAG37542
EAW91740
EAW91741
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