Homo sapiens Protein: RAD21L1
Summary
InnateDB Protein IDBP-292507.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD21L1
Protein Name RAD21-like 1 (S. pombe)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385925
InnateDB Gene IDBG-401959 (RAD21L1)
Protein Structure
UniProt Annotation
Function Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007059 chromosome segregation
GO:0007128 meiotic prophase I
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0030893 meiotic cohesin complex
Protein Structure and Domains
PDB ID
InterPro IPR006910 Rad21/Rec8-like protein, N-terminal
PFAM PF04825
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H4I0
PhosphoSite PhosphoSite-Q9H4I0
TrEMBL
UniProt Splice Variant
Entrez Gene 642636
UniGene Hs.713451
RefSeq
HUGO HGNC:16271
OMIM
CCDS
HPRD
IMGT
EMBL AL031665 AL136531 BC157891 BC171911
GenPept AAI57892 AAI71911 CAC10381 CAO03527 CAX15025