InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAD21L1

Summary

InnateDB Protein

IDBP-292508.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD21L1

Protein Name

RAD21-like 1 (S. pombe)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386414

InnateDB Gene

IDBG-401959 (RAD21L1)

Protein Structure

UniProt Annotation

Function

Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006302	double-strand break repair
GO:0007059	chromosome segregation
GO:0007128	meiotic prophase I
GO:0007129	synapsis
GO:0007283	spermatogenesis
GO:0009566	fertilization
GO:0030999	linear element assembly
GO:0070197	attachment of telomeric heterochromatin to nuclear envelope
GO:0072520	seminiferous tubule development

Cellular Component

GO:0000228	nuclear chromosome
GO:0000800	lateral element
GO:0005634	nucleus
GO:0005694	chromosome
GO:0030893	meiotic cohesin complex
GO:0034991	nuclear meiotic cohesin complex