InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR12

Summary

InnateDB Protein

IDBP-292566.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR12

Protein Name

G protein-coupled receptor 12

Synonyms

GPCR12; GPCR21; PPP1R84;

Species

Homo sapiens

Ensembl Protein

ENSP00000384932

InnateDB Gene

IDBG-18143 (GPR12)

Protein Structure

UniProt Annotation

Function

Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0031210	phosphatidylcholine binding

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000599 G protein-coupled receptor 12
IPR000723 G protein-coupled receptor 3/6/12 orphan
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00650
PR00644

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P47775