Homo sapiens Protein: MTIF3
Summary
InnateDB Protein IDBP-292586.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTIF3
Protein Name mitochondrial translational initiation factor 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000384659
InnateDB Gene IDBG-19204 (MTIF3)
Protein Structure
UniProt Annotation
Function IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. {ECO:0000269PubMed:12095986}.
Subcellular Localization Mitochondrion {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0008135 translation factor activity, nucleic acid binding
GO:0043024 ribosomal small subunit binding
Biological Process
GO:0001732 formation of translation initiation complex
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR019814 Translation initiation factor 3, N-terminal
IPR019815 Translation initiation factor 3, C-terminal
PFAM PF05198
PF00707
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H2K0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 219402
UniGene
RefSeq XP_006719836
HUGO HGNC:29788
OMIM
CCDS CCDS9322
HPRD 17609
IMGT
EMBL AF265440 AF410851 AL137059 BC039599 BC046166
GenPept AAG44698 AAH39599 AAH46166 AAL04150 CAH70316