InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADRA2C

Summary

InnateDB Protein

IDBP-292598.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA2C

Protein Name

adrenergic, alpha-2C-, receptor

Synonyms

ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR;

Species

Homo sapiens

Ensembl Protein

ENSP00000386069

InnateDB Gene

IDBG-114355 (ADRA2C)

Protein Structure

UniProt Annotation

Function

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004938	alpha2-adrenergic receptor activity
GO:0005515	protein binding
GO:0031694	alpha-2A adrenergic receptor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051379	epinephrine binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0007596	blood coagulation
GO:0010700	negative regulation of norepinephrine secretion
GO:0030168	platelet activation
GO:0032148	activation of protein kinase B activity
GO:0032811	negative regulation of epinephrine secretion
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0044281	small molecule metabolic process
GO:0045666	positive regulation of neuron differentiation
GO:0045907	positive regulation of vasoconstriction
GO:0050796	regulation of insulin secretion
GO:0051930	regulation of sensory perception of pain
GO:0070473	negative regulation of uterine smooth muscle contraction
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043679	axon terminus

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000735 Alpha 2C adrenoceptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00560
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P18825