InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBL1X

Summary

InnateDB Protein

IDBP-292618.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBL1X

Protein Name

transducin (beta)-like 1X-linked

Synonyms

EBI; SMAP55; TBL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000385988

InnateDB Gene

IDBG-42498 (TBL1X)

Protein Structure

UniProt Annotation

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. {ECO:0000269PubMed:14980219}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10330347}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0042393	histone binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006508	proteolysis
GO:0007219	Notch signaling pathway
GO:0007605	sensory perception of sound
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005876	spindle microtubule
GO:0017053	transcriptional repressor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR006594 LisH dimerisation motif
IPR013720 LisH dimerisation motif, subgroup
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF08513

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00667

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt