InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC7A4

Summary

InnateDB Protein

IDBP-292646.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC7A4

Protein Name

solute carrier family 7 (orphan transporter), member 4

Synonyms

CAT-4; CAT4; HCAT3; VH;

Species

Homo sapiens

Ensembl Protein

ENSP00000384278

InnateDB Gene

IDBG-1922 (SLC7A4)

Protein Structure

UniProt Annotation

Function

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015171	amino acid transmembrane transporter activity
GO:0015174	basic amino acid transmembrane transporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006520	cellular amino acid metabolic process
GO:0006810	transport
GO:0015802	basic amino acid transport
GO:0055085	transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002293 Amino acid/polyamine transporter I
IPR004841 Amino acid permease/ SLC12A domain

PFAM

PF13520
PF00324

PRINTS

PIRSF

PIRSF006060

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43246

PhosphoSite

PhosphoSite-O43246

TrEMBL

C9JM63

UniProt Splice Variant

Entrez Gene

6545

UniGene

Hs.197116

RefSeq

XP_005261773

HUGO

HGNC:11062

OMIM

603752

CCDS

CCDS33608

HPRD

04780

IMGT

EMBL

AC002472 AJ000730 BC008814 BC062565 BC107160 BC107161 CR456580

GenPept

AAH08814 AAH62565 AAI07161 AAI07162 CAA04263 CAG30466