Version 5.4
Homo sapiens Protein: JAKMIP1
Summary
InnateDB Protein IDBP-292653.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JAKMIP1
Protein Name janus kinase and microtubule interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000386711
InnateDB Gene IDBG-8838 (JAKMIP1)
Protein Structure
UniProt Annotation
Function Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. {ECO:0000269PubMed:14718537, ECO:0000269PubMed:15277531, ECO:0000269PubMed:17532644}.
Subcellular Localization Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.
Disease Associations
Tissue Specificity Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine. {ECO:0000269PubMed:15277531, ECO:0000269PubMed:17761393}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019894 kinesin binding
GO:0019900 kinase binding
GO:0050811 GABA receptor binding
Biological Process
GO:0015031 protein transport
GO:0050890 cognition
Cellular Component
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
GO:0019898 extrinsic component of membrane
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96N16
PhosphoSite PhosphoSite-Q96N16
TrEMBL F2Z2K5
UniProt Splice Variant
Entrez Gene 152789
UniGene Hs.479066
RefSeq NP_001092903
HUGO HGNC:26460
OMIM 611195
CCDS CCDS47005
HPRD 11292
IMGT
EMBL AC092442 AC113615 AK056126 AK098536 AK295339 AM412307 AM412308 AM412309 AM412310 AY382340 BC047075 CH471131
GenPept AAH47075 AAR26235 BAB71098 BAC05325 BAG58310 CAL80778 CAL80779 CAL80780 CAL80781 EAW82401 EAW82402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca