Version 5.4
Homo sapiens Protein: THTPA
Summary
InnateDB Protein IDBP-292731.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THTPA
Protein Name thiamine triphosphatase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000384580
InnateDB Gene IDBG-547392 (THTPA)
Protein Structure
UniProt Annotation
Function Hydrolase highly specific for thiamine triphosphate (ThTP). {ECO:0000269PubMed:11827967, ECO:0000269PubMed:23707715}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11827967}.
Disease Associations
Tissue Specificity Widely expressed but at a low level. {ECO:0000269PubMed:11827967}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0016787 hydrolase activity
GO:0050333 thiamin-triphosphatase activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006772 thiamine metabolic process
GO:0016311 dephosphorylation
GO:0042357 thiamine diphosphate metabolic process
GO:0042723 thiamine-containing compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR012177 Thiamine triphosphatase
IPR023577 CYTH-like domain
PFAM PF01928
PRINTS
PIRSF PIRSF036561
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BU02
PhosphoSite PhosphoSite-Q9BU02
TrEMBL G3V5B9
UniProt Splice Variant
Entrez Gene 79178
UniGene
RefSeq NP_077304
HUGO HGNC:18987
OMIM 611612
CCDS CCDS32053
HPRD 15505
IMGT
EMBL AF432862 AK057691 AL135999 BC002984 BX161435 BX378775 CH471078
GenPept AAH02984 AAM22403 BAB71546 CAD61907 EAW66140 EAW66141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca