InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INO80

Summary

InnateDB Protein

IDBP-292765.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INO80

Protein Name

INO80 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384686

InnateDB Gene

IDBG-6884 (INO80)

Protein Structure

UniProt Annotation

Function

DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. {ECO:0000269PubMed:16230350, ECO:0000269PubMed:16298340, ECO:0000269PubMed:17721549, ECO:0000269PubMed:20237820, ECO:0000269PubMed:20687897, ECO:0000269PubMed:20855601, ECO:0000269PubMed:21303910}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00746, ECO:0000269PubMed:16298340, ECO:0000269PubMed:18026119, ECO:0000269PubMed:20971067}. Note=Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner.

Disease Associations

Tissue Specificity

According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas. {ECO:0000269PubMed:10574462, ECO:0000269PubMed:16298340}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	33 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0043014	alpha-tubulin binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000724	double-strand break repair via homologous recombination
GO:0006200	ATP catabolic process
GO:0006302	double-strand break repair
GO:0006338	chromatin remodeling
GO:0010571	positive regulation of nuclear cell cycle DNA replication
GO:0030307	positive regulation of cell growth
GO:0032508	DNA duplex unwinding
GO:0034644	cellular response to UV
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051225	spindle assembly
GO:0070914	UV-damage excision repair
GO:0071479	cellular response to ionizing radiation
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005874	microtubule
GO:0031011	Ino80 complex

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ULG1