InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DERL3

Summary

InnateDB Protein

IDBP-292795.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DERL3

Protein Name

Der1-like domain family, member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384744

InnateDB Gene

IDBG-2596 (DERL3)

Protein Structure

UniProt Annotation

Function

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. {ECO:0000269PubMed:16449189, ECO:0000269PubMed:22607976}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:16449189}; Multi-pass membrane protein {ECO:0000269PubMed:16449189}.

Disease Associations

Tissue Specificity

Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine. {ECO:0000269PubMed:16449189}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response