InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP4F11

Summary

InnateDB Protein

IDBP-292869.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4F11

Protein Name

cytochrome P450, family 4, subfamily F, polypeptide 11

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384588

InnateDB Gene

IDBG-35111 (CYP4F11)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle. {ECO:0000269PubMed:10964514}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0006954	inflammatory response
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00464
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9HBI6