InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPPC

Summary

InnateDB Protein

IDBP-292910.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPPC

Protein Name

natriuretic peptide C

Synonyms

CNP; CNP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000387159

InnateDB Gene

IDBG-83164 (NPPC)

Protein Structure

UniProt Annotation

Function

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0042803	protein homodimerization activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001503	ossification
GO:0001666	response to hypoxia
GO:0003418	growth plate cartilage chondrocyte differentiation
GO:0003419	growth plate cartilage chondrocyte proliferation
GO:0006182	cGMP biosynthetic process
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0009791	post-embryonic development
GO:0030814	regulation of cAMP metabolic process
GO:0030823	regulation of cGMP metabolic process
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0040014	regulation of multicellular organism growth
GO:0042493	response to drug
GO:0044702	single organism reproductive process
GO:0045471	response to ethanol
GO:0045669	positive regulation of osteoblast differentiation
GO:0045909	positive regulation of vasodilation
GO:0048513	organ development
GO:0048660	regulation of smooth muscle cell proliferation
GO:0050880	regulation of blood vessel size
GO:0051053	negative regulation of DNA metabolic process
GO:0051447	negative regulation of meiotic cell cycle
GO:1900194	negative regulation of oocyte maturation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0030141	secretory granule

Protein Structure and Domains

PDB ID

InterPro

IPR000663 Natriuretic peptide
IPR002406 Natriuretic peptide, C type
IPR002407 Natriuretic peptide, atrial type
IPR002408 Natriuretic peptide, brain type

PFAM

PF00212

PRINTS

PR00710
PR00713
PR00711
PR00712

PIRSF

SMART

SM00183

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt