Version 5.4
Homo sapiens Protein: EHBP1
Summary
InnateDB Protein IDBP-293064.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EHBP1
Protein Name EH domain binding protein 1
Synonyms HPC12; NACSIN;
Species Homo sapiens
Ensembl Protein ENSP00000385524
InnateDB Gene IDBG-53534 (EHBP1)
Protein Structure
UniProt Annotation
Function May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. {ECO:0000269PubMed:14676205}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14676205}. Membrane {ECO:0000269PubMed:14676205}. Note=Mostly found in cytosol and plasma membrane.
Disease Associations Prostate cancer, hereditary, 12 (HPC12) [MIM:611868]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
IPR022735 Domain of unknown function DUF3585
PFAM PF00307
PF11971
PF12130
PRINTS
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NDI1
PhosphoSite PhosphoSite-Q8NDI1
TrEMBL C9JEP1
UniProt Splice Variant
Entrez Gene 23301
UniGene Hs.271667
RefSeq NP_001136086
HUGO HGNC:29144
OMIM 609922
CCDS CCDS46299
HPRD 10109
IMGT
EMBL AB020710 AC007098 AC009501 AC092155 AC092567 AK000828 AK000986 AL833968 AY331186 AY531390 BC029477 BC067215
GenPept AAH29477 AAH67215 AAQ97141 AAS48537 AAX82024 AAY14789 AAY24356 BAA74926 BAA91391 BAG50844 CAD38814

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca