InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZC3H12D

Summary

InnateDB Protein

IDBP-293069.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZC3H12D

Protein Name

zinc finger CCCH-type containing 12D

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386616

InnateDB Gene

IDBG-97724 (ZC3H12D)

Protein Structure

UniProt Annotation

Function

May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation. {ECO:0000269PubMed:17210687, ECO:0000269PubMed:19531561, ECO:0000305}.

Subcellular Localization

Isoform 1: Cytoplasm. Note=Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.Isoform 3: Cytoplasm. Nucleus.

Disease Associations

Note=A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed.

Tissue Specificity

Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines. {ECO:0000269PubMed:19531561}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004519	endonuclease activity
GO:0046872	metal ion binding

Biological Process

GO:0030308	negative regulation of cell growth
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle