InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAD54L2

Summary

InnateDB Protein

IDBP-293140.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD54L2

Protein Name

RAD54-like 2 (S. cerevisiae)

Synonyms

ARIP4; HSPC325; SRISNF2L;

Species

Homo sapiens

Ensembl Protein

ENSP00000386520

InnateDB Gene

IDBG-37490 (RAD54L2)

Protein Structure

UniProt Annotation

Function

DNA helicase that modulates androgen receptor (AR)- dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Localizes in speckle-like nuclear compartments. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003712	transcription cofactor activity
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0019901	protein kinase binding

Biological Process

GO:0008152	metabolic process
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF04851

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y4B4