InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MDK

Summary

InnateDB Protein

IDBP-293244.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDK

Protein Name

midkine (neurite growth-promoting factor 2)

Synonyms

ARAP; MK; NEGF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000385451

InnateDB Gene

IDBG-41723 (MDK)

Protein Structure

UniProt Annotation

Function

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. {ECO:0000269PubMed:17379400}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0001662	behavioral fear response
GO:0007165	signal transduction
GO:0007219	Notch signaling pathway
GO:0007399	nervous system development
GO:0007614	short-term memory
GO:0009611	response to wounding
GO:0009725	response to hormone
GO:0016477	cell migration
GO:0021542	dentate gyrus development
GO:0021681	cerebellar granular layer development
GO:0021766	hippocampus development
GO:0021987	cerebral cortex development
GO:0030154	cell differentiation
GO:0030325	adrenal gland development
GO:0030421	defecation
GO:0042493	response to drug
GO:0043524	negative regulation of neuron apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050795	regulation of behavior
GO:0051384	response to glucocorticoid
GO:0051781	positive regulation of cell division
GO:1901215	negative regulation of neuron death

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR000762 Midkine heparin-binding growth factor
IPR020089 Pleiotrophin/Midkine, N-terminal domain
IPR020090 Pleiotrophin/Midkine, C-terminal domain
IPR020091 Pleiotrophin/Midkine disulphide-rich domain

PFAM

PF05196
PF01091

PRINTS

PR00269

PIRSF

SMART

SM00193

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt