InnateDB Protein
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IDBP-293270.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMEFF2
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Protein Name
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transmembrane protein with EGF-like and two follistatin-like domains 2
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Synonyms
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CT120.2; HPP1; TENB2; TPEF; TR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386871
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InnateDB Gene
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IDBG-77711 (TMEFF2)
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Protein Structure
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Function |
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. {ECO:0000269PubMed:10903839, ECO:0000269PubMed:17942404}.
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Subcellular Localization |
Isoform 1: Membrane {ECO:0000305}; Single- pass type I membrane protein {ECO:0000305}.Isoform 2: Membrane {ECO:0000305}; Single- pass type I membrane protein {ECO:0000305}.Isoform 3: Secreted.
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Disease Associations |
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Tissue Specificity |
Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. {ECO:0000269PubMed:10903839, ECO:0000269PubMed:10987305, ECO:0000269PubMed:11120884, ECO:0000269PubMed:11668495, ECO:0000269PubMed:16439095, ECO:0000269PubMed:16805794}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002350
Kazal domain
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PFAM |
PF00050
PF07648
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PRINTS |
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PIRSF |
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SMART |
SM00280
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UIK5
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PhosphoSite |
PhosphoSite-Q9UIK5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23671
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UniGene |
Hs.144513
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RefSeq |
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HUGO |
HGNC:11867
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OMIM |
605734
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CCDS |
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HPRD |
05760
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IMGT |
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EMBL |
AB004064
AB017269
AC092644
AC098617
AF179274
AF242221
AF242222
AF264150
AK074507
AK222691
AL157430
AY358907
BC008973
CR457390
DQ133599
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GenPept |
AAD55776
AAF91397
AAG49451
AAG49452
AAH08973
AAQ89266
AAX88893
AAY14874
AAZ43216
BAA87897
BAA90820
BAC11030
BAD96411
CAB75654
CAG33671
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