Version 5.4
Homo sapiens Protein: CALN1
Summary
InnateDB Protein IDBP-293283.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALN1
Protein Name calneuron 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000384354
InnateDB Gene IDBG-19152 (CALN1)
Protein Structure
UniProt Annotation
Function Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning. {ECO:0000250}.
Subcellular Localization Golgi apparatus, trans-Golgi network membrane {ECO:0000305PubMed:19338761}; Single-pass type IV membrane protein {ECO:0000305PubMed:19338761}. Cytoplasm, perinuclear region {ECO:0000269PubMed:19338761}. Cell membrane {ECO:0000305PubMed:19338761}; Single-pass type IV membrane protein {ECO:0000305PubMed:19338761}.
Disease Associations
Tissue Specificity Brain specific.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0032588 trans-Golgi network membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXU9
PhosphoSite PhosphoSite-
TrEMBL Q75MW5
UniProt Splice Variant
Entrez Gene 83698
UniGene Hs.592750
RefSeq
HUGO HGNC:13248
OMIM 607176
CCDS
HPRD 06209
IMGT
EMBL AC004845 AC004905 AC005011 AC006334 AC067941 AC092424 AC092785 AF282250 AY007302 BC020200 CH471140
GenPept AAG09620 AAH20200 AAK15155 AAS02041 AAS07507 EAX07902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca