InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALCRL

Summary

InnateDB Protein

IDBP-293349.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALCRL

Protein Name

calcitonin receptor-like

Synonyms

CGRPR; CRLR;

Species

Homo sapiens

Ensembl Protein

ENSP00000386972

InnateDB Gene

IDBG-77141 (CALCRL)

Protein Structure

UniProt Annotation

Function

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. {ECO:0000250, ECO:0000269PubMed:22102369}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Predominantly expressed in the lung and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001605	adrenomedullin receptor activity
GO:0001635	calcitonin gene-related polypeptide receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004948	calcitonin receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0001525	angiogenesis
GO:0006171	cAMP biosynthetic process
GO:0006816	calcium ion transport
GO:0006937	regulation of muscle contraction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0015031	protein transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0071329	cellular response to sucrose stimulus

Cellular Component

GO:0005764	lysosome
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001688 GPCR, family 2, calcitonin receptor
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003287 GPCR, family 2, calcitonin receptor family
IPR003289 GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR00361
PR01350
PR01351

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt