InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOBEC3A

Summary

InnateDB Protein

IDBP-293496.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOBEC3A

Protein Name

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384359

InnateDB Gene

IDBG-7865 (APOBEC3A)

Protein Structure

UniProt Annotation

Function

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269PubMed:10469298, ECO:0000269PubMed:12859895, ECO:0000269PubMed:16527742, ECO:0000269PubMed:19461882, ECO:0000269PubMed:20062055, ECO:0000269PubMed:20615867, ECO:0000269PubMed:21123384, ECO:0000269PubMed:21368204, ECO:0000269PubMed:21460793, ECO:0000269PubMed:21496894, ECO:0000269PubMed:22457529, ECO:0000269PubMed:22896697}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. {ECO:0000269PubMed:11863358, ECO:0000269PubMed:16527742, ECO:0000269PubMed:20062055, ECO:0000269PubMed:20308164}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0047844	deoxycytidine deaminase activity

Biological Process

GO:0009972	cytidine deamination
GO:0010529	negative regulation of transposition
GO:0044356	clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0070383	DNA cytosine deamination
GO:0071466	cellular response to xenobiotic stimulus
GO:0080111	DNA demethylation