Version 5.4
Homo sapiens Protein: RHCG
Summary
InnateDB Protein IDBP-29354.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHCG
Protein Name Rh family, C glycoprotein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000268122
InnateDB Gene IDBG-29352 (RHCG)
Protein Structure
UniProt Annotation
Function Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion. {ECO:0000269PubMed:11062476, ECO:0000269PubMed:14761968, ECO:0000269PubMed:15929723, ECO:0000269PubMed:16477434}.
Subcellular Localization Apical cell membrane {ECO:0000269PubMed:10852913, ECO:0000269PubMed:12204676}; Multi- pass membrane protein {ECO:0000269PubMed:10852913, ECO:0000269PubMed:12204676}. Note=Also detected at the basolateral membrane and in subapical vesicles. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney. {ECO:0000269PubMed:10852913, ECO:0000269PubMed:11062476, ECO:0000269PubMed:12204676}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008519 ammonium transmembrane transporter activity
GO:0030506 ankyrin binding
Biological Process
GO:0006873 cellular ion homeostasis
GO:0006885 regulation of pH
GO:0015696 ammonium transport
GO:0015837 amine transport
GO:0030855 epithelial cell differentiation
GO:0042592 homeostatic process
GO:0055085 transmembrane transport
GO:0070634 transepithelial ammonium transport
GO:0072488 ammonium transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002229 Blood group Rhesus C/E/D polypeptide
IPR024041 Ammonium transporter AmtB-like domain
PFAM PF00909
PRINTS PR00342
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBD6
PhosphoSite PhosphoSite-Q9UBD6
TrEMBL
UniProt Splice Variant
Entrez Gene 51458
UniGene Hs.459284
RefSeq NP_057405
HUGO HGNC:18140
OMIM 605381
CCDS CCDS10351
HPRD 16102
IMGT
EMBL AC013391 AF081497 AF193809 AF219981 AF219982 AF219983 AF219984 AF219985 AF219986 AF284446 AK290899 AK313238 AY257182 BC030965 CH471101
GenPept AAD55748 AAF19372 AAG02171 AAG02414 AAH30965 AAP81044 BAF83588 BAG36049 EAX02051

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca