Homo sapiens Protein: DNAH10 | |||||||||
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Summary | |||||||||
InnateDB Protein | IDBP-293650.5 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | DNAH10 | ||||||||
Protein Name | dynein, axonemal, heavy chain 10 | ||||||||
Synonyms | |||||||||
Species | Homo sapiens | ||||||||
Ensembl Protein | ENSP00000386770 | ||||||||
InnateDB Gene | IDBG-63750 (DNAH10) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain. {ECO:0000250}. | ||||||||
Subcellular Localization | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}. | ||||||||
Disease Associations | |||||||||
Tissue Specificity | Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart. | ||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||
PDB ID | |||||||||
InterPro |
IPR003593
AAA+ ATPase domain IPR004273 Dynein heavy chain domain IPR011704 ATPase, dynein-related, AAA domain IPR013594 Dynein heavy chain, domain-1 IPR013602 Dynein heavy chain, domain-2 IPR015424 Pyridoxal phosphate-dependent transferase IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF03028
PF07728 PF08385 PF08393 |
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PRINTS | |||||||||
PIRSF | |||||||||
SMART |
SM00382
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TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | Q8IVF4 | ||||||||
PhosphoSite | PhosphoSite-Q8IVF4 | ||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 196385 | ||||||||
UniGene | Hs.622654 | ||||||||
RefSeq | NP_997320 | ||||||||
HUGO | HGNC:2941 | ||||||||
OMIM | 605884 | ||||||||
CCDS | CCDS9255 | ||||||||
HPRD | 13477 | ||||||||
IMGT | |||||||||
EMBL | AB095937 AC079315 AC117503 AJ132089 AK095581 AK125475 AK125796 | ||||||||
GenPept | BAC04579 BAC23113 BAC86173 BAC86296 CAA10562 | ||||||||