Version 5.4
Homo sapiens Protein: DYNC2LI1
Summary
InnateDB Protein IDBP-293756.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DYNC2LI1
Protein Name dynein, cytoplasmic 2, light intermediate chain 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385738
InnateDB Gene IDBG-49053 (DYNC2LI1)
Protein Structure
UniProt Annotation
Function May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localizes to the apical cytoplasm. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005515 protein binding
Biological Process
GO:0008152 metabolic process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005829 cytosol
GO:0005858 axonemal dynein complex
GO:0005881 cytoplasmic microtubule
GO:0005930 axoneme
GO:0030990 intraciliary transport particle
GO:0031512 motile primary cilium
GO:0036064 ciliary basal body
GO:0045177 apical part of cell
GO:0072372 primary cilium
Protein Structure and Domains
PDB ID
InterPro IPR022780 Dynein family light intermediate chain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF05783
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TCX1
PhosphoSite PhosphoSite-Q8TCX1
TrEMBL
UniProt Splice Variant
Entrez Gene 51626
UniGene Hs.371597
RefSeq NP_056337
HUGO HGNC:24595
OMIM
CCDS CCDS46270
HPRD 13116
IMGT
EMBL AC011242 AF151818 AK223432 AL050006 AY083346 BC006969 BC016324 BC040558 BC058823 CH471053
GenPept AAD34055 AAH06969 AAH16324 AAH40558 AAH58823 AAL99216 AAY14702 BAD97152 CAB43233 EAX00289 EAX00290 EAX00291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca