InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ILK

Summary

InnateDB Protein

IDBP-29383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ILK

Protein Name

integrin-linked kinase

Synonyms

HEL-S-28; ILK-1; ILK-2; P59; p59ILK;

Species

Homo sapiens

Ensembl Protein

ENSP00000299421

InnateDB Gene

IDBG-29381 (ILK)

Protein Structure

UniProt Annotation

Function

Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Subcellular Localization

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, myofibril, sarcomere.

Disease Associations

Tissue Specificity

Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	149 [view]
Protein-Protein	147 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0008283	cell proliferation
GO:0009966	regulation of signal transduction
GO:0034329	cell junction assembly
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042327	positive regulation of phosphorylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0030017	sarcomere
GO:0030027	lamellipodium
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016253 Integrin-linked protein kinase
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00069
PF07714
PF00023
PF13606
PF11929
PF12796

PRINTS

PR00109
PR01415

PIRSF

PIRSF000654

SMART

SM00248
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References