InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSMD14

Summary

InnateDB Protein

IDBP-293881.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMD14

Protein Name

proteasome (prosome, macropain) 26S subunit, non-ATPase, 14

Synonyms

PAD1; POH1; RPN11;

Species

Homo sapiens

Ensembl Protein

ENSP00000386541

InnateDB Gene

IDBG-73577 (PSMD14)

Protein Structure

UniProt Annotation

Function

Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. {ECO:0000269PubMed:22909820, ECO:0000269PubMed:9374539}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. Highest levels in heart and skeletal muscle. {ECO:0000269PubMed:9374539}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	102 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding
GO:0061133	endopeptidase activator activity
GO:0070628	proteasome binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0000724	double-strand break repair via homologous recombination
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467	gene expression
GO:0010950	positive regulation of endopeptidase activity
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0061136	regulation of proteasomal protein catabolic process
GO:0070536	protein K63-linked deubiquitination

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0008541	proteasome regulatory particle, lid subcomplex
GO:0022624	proteasome accessory complex
GO:0070062	extracellular vesicular exosome