InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERMN

Summary

InnateDB Protein

IDBP-293993.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERMN

Protein Name

ermin, ERM-like protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387047

InnateDB Gene

IDBG-72862 (ERMN)

Protein Structure

UniProt Annotation

Function

Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in adult and fetal brain. Expressed at intermediate levels in the lung and liver. {ECO:0000269PubMed:10574461}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding

Biological Process

GO:0007015	actin filament organization
GO:0008360	regulation of cell shape
GO:0031344	regulation of cell projection organization

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005938	cell cortex
GO:0033269	internode region of axon
GO:0033270	paranode region of axon
GO:0070062	extracellular vesicular exosome