Version 5.4
Homo sapiens Protein: TAS2R40
Summary
InnateDB Protein IDBP-294003.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAS2R40
Protein Name taste receptor, type 2, member 40
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000386210
InnateDB Gene IDBG-281701 (TAS2R40)
Protein Structure
UniProt Annotation
Function Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0033038 bitter taste receptor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050909 sensory perception of taste
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007960 Mammalian taste receptor
PFAM PF05296
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P59535
PhosphoSite PhosphoSite-P59535
TrEMBL Q50KK6
UniProt Splice Variant
Entrez Gene 259286
UniGene Hs.352241
RefSeq NP_795363
HUGO HGNC:18885
OMIM 613964
CCDS CCDS43662
HPRD 18150
IMGT
EMBL AB199167 AB199168 AB199169 AF494229 AY724957 BC101795 BC101797 CH236959 CH471198
GenPept AAI01796 AAI01798 AAM19320 AAU21153 BAD98041 BAD98042 BAD98043 EAL23782 EAW51882

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca