InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF2AK2

Summary

InnateDB Protein

IDBP-294053.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2AK2

Protein Name

eukaryotic translation initiation factor 2-alpha kinase 2

Synonyms

EIF2AK1; PKR; PPP1R83; PRKR;

Species

Homo sapiens

Ensembl Protein

ENSP00000385014

InnateDB Gene

IDBG-44867 (EIF2AK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 134 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	134 [view]
Protein-Protein	120 [view]
Protein-DNA	10 [view]
Protein-RNA	2 [view]
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001819	positive regulation of cytokine production
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0017148	negative regulation of translation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019048	modulation by virus of host morphology or physiology
GO:0019054	modulation by virus of host process
GO:0019058	viral life cycle
GO:0030683	evasion or tolerance by virus of host immune response
GO:0032722	positive regulation of chemokine production
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0033689	negative regulation of osteoblast proliferation
GO:0035455	response to interferon-alpha
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:1900225	regulation of NLRP3 inflammasome complex assembly
GO:1901224	positive regulation of NIK/NF-kappaB signaling
GO:1901532	regulation of hematopoietic progenitor cell differentiation
GO:1902033	regulation of hematopoietic stem cell proliferation
GO:1902036	regulation of hematopoietic stem cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014720 Double-stranded RNA-binding domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00035

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00358
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt