InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTMR2

Summary

InnateDB Protein

IDBP-294080.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTMR2

Protein Name

myotubularin related protein 2

Synonyms

CMT4B; CMT4B1;

Species

Homo sapiens

Ensembl Protein

ENSP00000386882

InnateDB Gene

IDBG-68604 (MTMR2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0002091	negative regulation of receptor internalization
GO:0006470	protein dephosphorylation
GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008219	cell death
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0044281	small molecule metabolic process
GO:0045806	negative regulation of endocytosis
GO:0090394	negative regulation of excitatory postsynaptic membrane potential
GO:0097062	dendritic spine maintenance
GO:2000643	positive regulation of early endosome to late endosome transport
GO:2000645	negative regulation of receptor catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0031901	early endosome membrane
GO:0043197	dendritic spine
GO:0097060	synaptic membrane
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

InterPro

IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR004182 GRAM domain
IPR010569 Myotubularin-like phosphatase domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF02893
PF06602

PRINTS

PIRSF

SMART

SM00404
SM00568

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13614