InnateDB Protein
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IDBP-294220.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TCHP
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Protein Name
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trichoplein, keratin filament binding
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384520
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InnateDB Gene
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IDBG-56504 (TCHP)
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Protein Structure
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Function |
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. {ECO:0000269PubMed:15731013, ECO:0000269PubMed:18931701}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion.
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Disease Associations |
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Tissue Specificity |
Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis. {ECO:0000269PubMed:18931701}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BT92
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PhosphoSite |
PhosphoSite-Q9BT92
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TrEMBL |
F5GWH6
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UniProt Splice Variant |
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Entrez Gene |
84260
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UniGene |
Hs.733214
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RefSeq |
NP_001137324
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HUGO |
HGNC:28135
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OMIM |
612654
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CCDS |
CCDS9137
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HPRD |
14403
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IMGT |
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EMBL |
AC084876
AK092736
AY007230
BC004285
CH471054
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GenPept |
AAG12971
AAH04285
BAC03960
EAW97883
EAW97884
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