Version 5.4
Homo sapiens Protein: PLEKHB2
Summary
InnateDB Protein IDBP-294229.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHB2
Protein Name pleckstrin homology domain containing, family B (evectins) member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000386662
InnateDB Gene IDBG-70065 (PLEKHB2)
Protein Structure
UniProt Annotation
Function Involved in retrograde transport of recycling endosomes. {ECO:0000269PubMed:21911378, ECO:0000269PubMed:22281740}.
Subcellular Localization Recycling endosome membrane {ECO:0000269PubMed:21911378, ECO:0000269PubMed:22281740}; Peripheral membrane protein {ECO:0000269PubMed:21911378, ECO:0000269PubMed:22281740}. Note=Specifically detected in tubulovesicular structures, and colocalizes with TFNR.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0055038 recycling endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96CS7
PhosphoSite PhosphoSite-Q96CS7
TrEMBL B4DJB7
UniProt Splice Variant
Entrez Gene 55041
UniGene Hs.739928
RefSeq NP_001094093
HUGO HGNC:19236
OMIM
CCDS CCDS46413
HPRD 15144
IMGT
EMBL AC009477 AC073869 AC131180 AK000790 AK123710 AK223338 AK293880 AK296008 AK302770 BC001428 BC013991 BC050695 CH471250
GenPept AAH01428 AAH13991 AAH50695 AAX93135 BAA91379 BAD97058 BAG53942 BAG57269 BAG58779 BAG63978 EAW51261 EAW51262 EAW51263 EAW51264 EAW51266

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca