InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDSR

Summary

InnateDB Protein

IDBP-294337.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDSR

Protein Name

3-ketodihydrosphingosine reductase

Synonyms

DHSR; FVT1; SDR35C1;

Species

Homo sapiens

Ensembl Protein

ENSP00000385083

InnateDB Gene

IDBG-4373 (KDSR)

Protein Structure

UniProt Annotation

Function

Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15328338}; Multi-pass membrane protein {ECO:0000269PubMed:15328338}.

Disease Associations

Note=A chromosomal aberration involving KDSR is a cause of follicular lymphoma; also known as type II chronic lymphatic leukemia. Translocation t(2;18)(p11;q21) with a Ig J kappa chain region.

Tissue Specificity

Expressed in all tissues examined. Highest expression in placenta. High expression in lung, kidney, stomach and small intestine, low expression in heart, spleen and skeletal muscle. Weakly expressed in normal hematopoietic tissues. Higher expression in some T-cell malignancies and PHA-stimulated lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity
GO:0047560	3-dehydrosphinganine reductase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006666	3-keto-sphinganine metabolic process
GO:0008152	metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01397

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt