InnateDB Protein
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IDBP-294345.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LIMS2
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Protein Name
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LIM and senescent cell antigen-like domains 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000387002
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InnateDB Gene
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IDBG-69173 (LIMS2)
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Protein Structure
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Function |
Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. {ECO:0000269PubMed:12167643}.
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Subcellular Localization |
Nucleus {ECO:0000305}. Cell junction, focal adhesion {ECO:0000269PubMed:12167643}. Cell membrane {ECO:0000269PubMed:12167643}; Peripheral membrane protein {ECO:0000269PubMed:12167643}; Cytoplasmic side {ECO:0000269PubMed:12167643}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001781
Zinc finger, LIM-type
IPR017351
LIM and senescent cell antigen-like-containing domain protein 1
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PFAM |
PF00412
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PRINTS |
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PIRSF |
PIRSF038003
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z4I7
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PhosphoSite |
PhosphoSite-Q7Z4I7
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TrEMBL |
Q9H058
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UniProt Splice Variant |
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Entrez Gene |
55679
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UniGene |
Hs.688940
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RefSeq |
NP_001154876
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HUGO |
HGNC:16084
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OMIM |
607908
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CCDS |
CCDS54394
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HPRD |
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IMGT |
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EMBL |
AC010976
AC074114
AF484961
AF520987
AF527764
AF527765
AF527766
AF527767
AF527770
AK022470
AK297645
AL512716
BC001370
BC008977
BC065816
BX458594
CH471103
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GenPept |
AAH01370
AAH08977
AAH65816
AAM77350
AAM97589
AAQ09011
AAQ09012
AAQ09013
AAQ09014
AAQ09017
BAB14047
BAG60013
CAC21657
EAW95327
EAW95331
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