Version 5.4
Homo sapiens Protein: TCN2
Summary
InnateDB Protein IDBP-294476.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCN2
Protein Name transcobalamin II
Synonyms D22S676; D22S750; II; TC; TC II; TC-2; TC2; TCII;
Species Homo sapiens
Ensembl Protein ENSP00000384914
InnateDB Gene IDBG-4271 (TCN2)
Protein Structure
UniProt Annotation
Function Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Subcellular Localization Secreted.
Disease Associations Transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]: Results in various forms of anemia. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006824 cobalt ion transport
GO:0009235 cobalamin metabolic process
GO:0015889 cobalamin transport
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005768 endosome
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002157 Cobalamin (vitamin B12)-binding transporter, eukaryotic
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
PFAM PF01122
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P20062
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 6948
UniGene
RefSeq NP_001171655
HUGO HGNC:11653
OMIM 613441
CCDS CCDS54519
HPRD 02037
IMGT
EMBL AC005006 AF047576 BC001176 BC011239 CR456591 L02647 L02648 M60396
GenPept AAA61054 AAA61056 AAA61057 AAC05491 AAH01176 AAH11239 CAG30477

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca